Abstract
Abstract Objective: In last years, numerous associations between immune system and pathogenesis of primary hypertension (PH) have been revealed. Also, experimental and adult data suggest that inflammation plays a major role in arteries stiffening. The aim of the study was to assess relation between low-grade inflammation and arterial damage in children with PH. Design and method: In the group of 119 pediatric patients with PH (14.94 ± 2.76 years, 86 boys, 33 girls) and 45 healthy children (14.91 ± 2.69 years, 27 boys, 18 d girls) we analyzed parameters of low-grade inflammation: neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and mean platelet volume (MPV), peripheral office blood pressure, ABPM, central blood pressure, parameters of arterial damage: aortic pulse wave velocity (aPWV) [m/s], [Z-score], augmentation index (AIx75HR [%]), common carotid artery intima media thickness (cIMT) [mm], [Z-score], carotid artery stiffness (E-tracking), and clinical and biochemical parameters. Results: Children with PH had higher NLR (1.93 ± 1.52 vs. 1.32 ± 0.44, p = 0.010), PLR (131.39 ± 41.87 vs. 114.68 ± 37.60, p = 0.020), MAP 24 h Z-score in ABPM (1.34 ± 1.38 vs. 0.43 ± 0.49, p = 0.002), aortic systolic blood pressure (AoSBP) (110.44 ± 9.95 vs. 101.50 ± 8.99 [mm Hg], p < 0.001), aPWV (5.36 ± 0.88 vs. 4.88 ± 0.92 [m/s], p = 0.004) and cIMT (0.46 ± 0.07 vs. 0.43 ± 0.07 [mm], p = 0.002) compared to healthy children. In children with PH NLR correlated (p < 0.05) positively with systolic, diastolic, and mean blood pressure in ABPM (r = 0,24, r = 0,22, r = 0,25), with aPWV [m/s], [Z-score] (r = 0,24, r = 0,20) and pulse wave velocity in carotid artery (PWVbeta) [m/s] (r = 0.20); no such correlations were found in healthy children. NLR, PLR, and MPV did not correlate with cIMT, age, and sex in either of the groups. Conclusions: In pediatric patients with primary hypertension arterial stiffness is related to degree of low-grade
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
