Abstract
Background: Alteration of arterial mechanical properties has adverse effects on cardiovascular disease in Marfan syndrome. Design: We compared central pulse pressure, augmentation index adjusted to a heart rate of 75 beats per minute (AIx@HR75) and pulse wave velocity in 25 Marfan patients who had under-gone an aortic valve-sparing reimplantation operation, in 15 Marfan patients after composite valve grafting operation, and in 40 age and sex-matched Mar-fan patients who had not undergone surgery. Results: Central pulse pressure, AIx@HR75 and pulse wave velocity were similar across all three patient groups. Exclusively AIx@HR75 was higher with conduit operations than in persons without any surgery (P = 0.03). Multivariate linear regression analysis documented association of AIx@HR75 with body height (P < 0.001) and with a history of aortic valve-sparing reimplantation operation (P < 0.001) or with a composite valve grafting operation (P = 0.006). Conclusions: Arterial mechanical properties are only mildly altered by surgery of the aortic root without difference between the reimplantation and conduit operation.
Highlights
Alteration of arterial mechanical properties relate to cardiovascular events in healthy individuals, and in persons with cardiovascular diseases [1], including those with the Marfan syndrome [2]
Design: We compared central pulse pressure, augmentation index adjusted to a heart rate of 75 beats per minute (AIx@HR75) and pulse wave velocity in 25 Marfan patients who had undergone an aortic valve-sparing reimplantation operation, in 15 Marfan patients after composite valve grafting operation, and in 40 age and sex-matched Marfan patients who had not undergone surgery
Hemodynamic findings at applanation tonometry were similar in all Marfan patients irrespective of presence or type of aortic root surgery
Summary
Alteration of arterial mechanical properties relate to cardiovascular events in healthy individuals, and in persons with cardiovascular diseases [1], including those with the Marfan syndrome [2]. Prophylactic replacement of the aortic root with a composite valve grafting operation according to Bentall (CVG) has improved life expectancy of affected persons significantly. Design: We compared central pulse pressure, augmentation index adjusted to a heart rate of 75 beats per minute (AIx@HR75) and pulse wave velocity in 25 Marfan patients who had undergone an aortic valve-sparing reimplantation operation, in 15 Marfan patients after composite valve grafting operation, and in 40 age and sex-matched Marfan patients who had not undergone surgery. Conclusions: Arterial mechanical properties are only mildly altered by surgery of the aortic root without difference between the reimplantation and conduit operation
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