Abstract
Staphylococcus pseudintermedius is a species often isolated from animals, as a common element of their microbiota or an agent of infection, and from people associated with an animal habitat, including owners of home pets—dogs and cats. As with many other species, adaptation of these bacteria to the human body can occur, and they become important human pathogens. 59 S. pseudintermedius strains were investigated in this study to determine the factors contributing to human body colonization: inhibition growth of human skin residents isolated from human skin (Staphylococcus epidermidis, Corynebacterium spp., Cutibacterium acnes (formerly Propionibacterium acnes)), biofilm formation, and the presence of ten genes encoding infection-promoting features (including ebpS, spsE, lukS, lukF, pvl, lip, hlgA, hlgB). The ability of human skin to be colonized and the presence of genes that promote the development of skin infections showed the significant potential of the studied strains in their adaptation to the host. However, while a comparison of the characteristics of animal strains and those isolated from human infections does not allow us to claim that we are the witnesses of the speciation of a new human pathogen, it does indicate their gradual adaptation to the human organism.
Highlights
Staphylococcus pseudintermedius belongs to the Staphylococcus intermedius group (SIG) which comprises Staphylococcus intermedius and Staphylococcus delphini (Savini et al 2013)
59 S. pseudintermedius strains were investigated in this study to determine the factors contributing to human body colonization: inhibition growth of human skin residents isolated from human skin (Staphylococcus epidermidis, Corynebacterium spp., Cutibacterium acnes), biofilm formation, and the presence of ten genes encoding infection-promoting features
Almost 80% of S. pseudintermedius strains exhibited an inhibitory effect on human skin microbiota, with the highest on epidermal staphylococci
Summary
Staphylococcus pseudintermedius belongs to the Staphylococcus intermedius group (SIG) which comprises Staphylococcus intermedius and Staphylococcus delphini (Savini et al 2013). S. pseudintermedius inhabits mainly companion animals such as pets (Jee et al 2007; Kmieciak and Szewczyk 2017; Wladyka et al 2015), but can cause infections in animals (Międzobrodzki et al 2010), most often otitis and skin infections (van Duijkeren et al 2011). These bacteria have been isolated from humans (Boost et al 2011; Savini et al 2014; Youn et al 2014). Animal pathogens gain more features that allow them to colonize human organisms and cause serious diseases. It is important to follow the changes of the original animal microorganisms in the context of current and future dangers to humans
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