Abstract
In the past two decades, comprehensive two-dimensional gas chromatography (GC×GC) has progressed from an interesting concept to the forefront of thinking and research in gas chromatography. Especially when combined with mass spectrometry detection, GC×GC provides high resolution, high sensitivity, and massive chromatographic data sets, which is useful in diverse fields such as petroleum analysis, metabolomics, food, flavor, fragrance, and environmental analysis. In this installment, recent developments in GC×GC that make it more amenable for routine use are discussed. These include advances in instrumentation, especially modulation, column sets, data analysis, and the range and types of samples amenable to GC×GC. We will ponder the question – are you ready to make the switch to GC×GC?
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