Abstract

1 Department of Medical Statistics London School of Hygiene and Tropical Medicine, UK 2 Leiden University Medical Center Dept. Clinical Epidemiology PO Box 9600 2300 RC Leiden, The Netherlands 3 Department of Clinical Epidemiology, Aarhus University, Denmark. Editor’s Note: Related articles can be found on pp. XXX, XXX, and XXX. Conflicts of interest: None declared Acknowledgments: We thank Matt Fox and Elizabeth Williamson for comments on the draft manuscript, and George Davey Smith for useful discussions of these issues. Correspondence to: Professor Neil Pearce Department of Medical Statistics London School of Hygiene and Tropical Medicine, UK Email: [email protected] Phone: 020-79588151

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