Are specific types of aneuploidy more common in high-risk patients undergoing preimplantation genetic diagnosis (PGD)?

Abstract

Cytogenetic analyses have shown that more than half of all preimplantation embryos contain aneuploidic cells. We have previously published data demonstrating that three groups of patients are at higher risk for aneuploidic embryos. 1.) Patients with recurrent pregnancy loss (RPL); 2.) Patients with advanced maternal age (AMA); 3.) Patients with repeated failed IVF cycles (FC). In an effort to determine if specific types of aneuploidies are more common in these high-risk groups, we retrospectively reviewed karyotypes of 188 embryos biopsied from 40 patients who had been prospectively randomized to undergo PGD from a total of 87 patients enrolled from Aug 1, 2001 − Dec 1, 2003.