Abstract
The effects of early postnatal treatment with testosterone propionate (TP) on the ultrastructure of the arcuate region, comprising the arcuate nucleus and adjacent median eminence, of adult anovulatory female rats were studied. Nerve propionate terminals ending on arcuate neurons in the TP-treated animals exhibited a decrease in dense-core vesicles (700–1200 Å), an increase in the number of clear vesicles, and of vesicles that exhibited various degrees of electron density. No changes in the morphology of neuronal cell bodies were observed between the TP-treated and control animals. The results suggest that the nature of the vesicles in nerve terminals ending on arcuate neurons is modified in androgenized rats. The changes observed might be attributed to either a direct effect of the testosterone, or an indirect effect of persistent estrogen acting on the arcuate nucleus of another area that has fiber connections with the arcuate nucleus.
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