Abstract
Background aimIn ethnomedicine, different parts of Chrysophyllum albidum have been used as herbal remedies for the treatment and management of various ailments. This study was carried out to determine the dose and duration dependent effects of administration of aqueous root extracts of Chrysophyllum albidum on the serum concentrations of some reproductive hormones and testes of the experimental rats.MethodsForty-five adult male Wistar rats were used for this study. They were randomized into 3 groups (groups 1, 2 & 3) of 15 rats each, with each group further randomized into 3 subgroups (subgroups 1a, 1b, 1c; 2a, 2b, 2c; 3a, 3b, 3c) of 5 rats each, according to the dose and duration of extract administration.ResultsAt the 8th week of extract administration, there were significantly (P < 0.05) higher concentrations of FSH in the treated subgroups while at weeks 6 and 8, there were significant (p < 0.05) increases in the serum concentrations of LH of the treated subgroups as compared to those of the control subgroups. Also, at weeks 6 and 8, administration of the extract resulted in significant (P < 0.05) increases in the concentrations of serum testosterone in the treated subgroups. Photomicrograph of the testes revealed focal spermatogenic arrest in the area biopsied in the treated subgroups (with low and high doses) at weeks 6 and 8 of extract administration.ConclusionThe administration of aqueous root extract of Chrysophyllum albidum to male Wistar rats at increasing doses and time duration may affect their fertility and calls for caution in the prolonged use of the plant in folk medicine.
Highlights
From time immemorial medicinal plants have been used in all cultures as a source of medicine [1]
Administration of the extract for 6 and 8 weeks resulted in significant (p < 0.05) increases in the serum concentrations of Luteinizing Hormone (LH) of the treated subgroups (2b &3b; 2c & 3c) as compared to those of the control subgroups (1b; 1c)
At the 6th and 8th weeks, administration of the extract resulted in significant (P < 0.05) increases in the concentrations of serum testosterone in the treated subgroups (2b, 2c & 3b, 3c) as compared to the control subgroups (1b, 1c)
Summary
From time immemorial medicinal plants have been used in all cultures as a source of medicine [1]. Medicinal plants are herbal remedies that are used for the treatment and management of ailments, and there exclusive use has served as one of the most vital approach accessible to man [3]. It is generally known that the Chrysophyllum albidum is an indigenous plant and an edible tropical fruit. It is a medicinal herb which belongs to the family Sapotaceae. Phytochemistry of Chrysophyllum albidum stem slash, seed cotyledon, leaves and root (2019) 5:3. Different parts of Chrysophyllum albidum have been used as herbal remedies for the treatment and management of various ailments. This study was carried out to determine the dose and duration dependent effects of administration of aqueous root extracts of Chrysophyllum albidum on the serum concentrations of some reproductive hormones and testes of the experimental rats
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