APPROBATION TRIALS OF A VACCINE AGAINST NEWCASTLE DISEASE FROM THE LA SOTA STRAIN

Abstract

the paper presents the results of an approbation test of the physical and biological properties of an experimental series of a vaccine against Newcastle disease from the La-Sota strain in the conditions of the National Reference Center for Veterinary Medicine of the Committee for Veterinary Control and Supervision of the Ministry of Agriculture of the Republic of Kazakhstan (CVC and SMA RK) and the Research Institute of Biological Problems security (RIBSP). The aim of the study was to test a vaccine against Newcastle disease from the La-Sota strain. When performing the work, general virological and immunological research methods were used. The results of approbation studies showed that the vaccine was free of contaminants and its biological activity was 9,03 ± 0,14 lg EID50/cm3. The vaccine is harmless to chickens of 40 days of age. The vaccine is immunogenic for chickens. The average titers of antibodies to the Newcastle disease virus on the 16th day after vaccination is 1:127,2 in the hemagglutination inhibition test (HITA). The vaccine meets all the required requirements in terms of its physico-biological properties and is suitable for specific prophylaxis of Newcastle disease. Approbation tests of the physical, biological properties of the vaccine were completed with positive results and protocols, research acts were signed by members of the Commission of the CVC and SMA RK. It is recommended to use the vaccine on a large scale in the conditions of poultry farms, private farmsteads for the specific prevention of Newcastle disease.