Abstract
In a tumor therapy model with spontaneous mammary tumors in mongrel dogs (1) using Vibrio cholerae neuraminidase (VCN)-treated autologous tumor cells success has been shown to depend on the number of cells injected. Tumor enhancement (1 × 108 cells), long-lasting tumor regression (2 × 107 cells) or only a transient therapeutic effect (2 × 106 cells) could be demonstrated. Moreover, it has been shown that distinct amounts of active VCN remain attached to the cell surface of VCN-treated cells (2,3,4) and that VCN admixed to a variety of antigens either structurally containing or lacking sialic acid, dose dependently acts as an adjuvant (5), predominantly for the cellular immune response (6).
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