Drug Discovery Today | VOL. 27

Approaches to advance drug discovery for neglected tropical diseases

Publication Date Aug 1, 2022


Neglected tropical diseases (NTDs), which include leishmaniasis, Chagas disease, human African trypanosomiasis (HAT), and schistosomiasis, remain public health problems in developing countries, as highlighted in the 2021-2030 WHO Roadmap on NTDs. This agenda sets the challenges for the control and elimination of NTDs by 2030. Fortunately, NTD drug discovery has shifted from traditional to modern strategies combining medicinal chemistry, phenotypic and molecular assays, multiparameter optimization, structural biology, and omics approaches. Structure- and ligand-based drug design have fostered NTD drug discovery by enabling data-driven molecular optimization, expansion to previously inaccessible chemical spaces, and knowledge building from biological data. These efforts have integrated parasite biology and medicinal chemistry to advance drug discovery in this key area of global health.


Neglected Tropical Diseases Elimination Of Neglected Tropical Diseases WHO Roadmap Human African Trypanosomiasis Ligand-based Drug Design Control Of Neglected Tropical Diseases Multiparameter Optimization Omics Approaches Drug Discovery Chagas Disease

Round-ups are the summaries of handpicked papers around trending topics published every week. These would enable you to scan through a collection of papers and decide if the paper is relevant to you before actually investing time into reading it.

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