Abstract
In the recent years, multidrug-resistant bacteria have become a global threat, and phage therapy may to be used as an alternative to antibiotics or, at least, as a supplementary approach to treatment of some bacterial infections. Here, we describe the results of bacteriophage application in clinical practice for the treatment of localized infections in wounds, burns, and trophic ulcers, including diabetic foot ulcers. This mini-review includes data from various studies available in English, as well as serial case reports published in Russian scientific literature (with, at least, abstracts accessible in English). Since, it would be impossible to describe all historical Russian publications; we focused on publications included clear data on dosage and rout of phage administration.
Highlights
Since their discovery, bacteriophages have been considered to be potential antibacterial therapeutics for the treatment of various infectious diseases in humans
The various localizations of bacterial infections require identification of the most preferable routes and therapeutic schemes of phage administration. In this mini-review, we focus on the results of phage therapy applied in the clinical treatment of localized infections in wounds, burns, and trophic ulcers, including diabetic foot ulcers
Topical application of phages led to the elimination of multiple drug resistant (MDR) P. aeruginosa or successful skin graft take in 18 of 30 patients with burns, but the method was time-consuming, and the authors recommended this therapy only for infections resistant to available antibiotics (AbulHassan et al, 1990)
Summary
Bacteriophages have been considered to be potential antibacterial therapeutics for the treatment of various infectious diseases in humans. Based on the obtained data, the authors have suggested that application of phage preparations provided positive effect in mono-infection, while complex therapy, including bacteriophages and antibiotics, was required in mixed bacterial infection (Kochetkova et al, 1989).
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