Abstract
BackgroundCellular communication is an essential feature of multicellular organisms. Binding of ligands to their homologous receptors, which activate specific cell signaling pathways, is a basic type of cellular communication and intimately linked to many degeneration processes leading to diseases.Main bodyThis study reviewed the history of ligand-receptor and presents the databases which store ligand-receptor pairs. The recently applications and research tools of ligand-receptor interactions for cell communication at single cell level by using single cell RNA sequencing have been sorted out.ConclusionThe summary of the advantages and disadvantages of analysis tools will greatly help researchers analyze cell communication at the single cell level. Learning cell communication based on ligand-receptor interactions by single cell RNA sequencing gives way to developing new target drugs and personalizing treatment.
Highlights
Cellular communication is an essential feature of multicellular organisms
Learning cell communication based on ligand-receptor interactions by single cell RNA sequencing gives way to developing new target drugs and personalizing treatment
The understanding of ligand-receptor interaction is the foundation for current studies of intercellular communication
Summary
Cell–cell communication governs the biological behaviors of multicellular populations. Ligand-receptor interactions, which is a vital type of cellular communication, have presented important roles in pharmacological research and disease progression as reviewed. The emergence of scRNA sequencing technology gives a new way that are closer to the actual action of organisms for the research of ligand-receptor interaction. Many studies have learning cellular communication based on ligand-receptor interaction by scRNA sequencing (Fig. 2), to identify ligand-receptor interactions as biomarkers or potential therapeutic targets. Tools or methods for learning ligand-receptor interactions by scRNA sequencing were developed, and sorted out in this study. It is expectant that us these tools to study diseases in more depth
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