Abstract
Objective To explore the application value of thymidine kinase 1(TK1) for breast cancer diagnosis and treatment.Methods Serum TK1 concentration and positive rate were detected respectively in 205 patients with breast cancer and 150 healthy cases control with western blot-enhanced chemiluminecence.Results TK1 average concentration of patients with breast cancer in untreated group was 2.65 pmol/L; and its positive rate was 67.7％.TK 1 average concentration of healthy control group was 0.96 pmol/L; and its positive rate was 12.7％.There was significant difference(P＜0.001) among groups.The TK1 average concentration and positive rate had significant difference (P＜0.001) among the breast cancer patients in the remission stage of treatment group,the poor prognosis group,and untreated group.Conclusion TK1 has certain value of clinical applications on breast cancer auxiliary diagnosis,curative effect monitoring during treatment,and prognosis estimate. Key words: Thymidine kinase 1 ; Breast cancer; Diagnosis; Treatment
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