Abstract
Turbidity technique was employed to study the mutual interaction of melittin and vitamin D2 with 1,2-dipalmitoyl phosphatidylcholine (DPPC) bilayers. In addition, the data obtained from the phase transition curve is used to calculate the main phase transition temperature, conformational stability and activation energy values by using two state transition thermodynamic approach. The results indicate that melittin decreases the main phase transition temperature and also dramatically decreases the stability. Melittin on its own has disordering effect on phospholipid membrane structure. At low concentrations (3, 6mol %) vitamin D2 does not alter the main phase transition temperature, whilst the main phase transition temperature significantly decreases upon addition of a high concentration of vitamin D2 (12mol %). Stability values of mutual interaction of vitamin D2 with DPPC indicates that vitamin D2 has an ordering effect. Moreover, the activation energy increases as vitamin D2 concentration increases.
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