Abstract
Objective To compare the efficacy and safety of sufentanil and fentanyl anesthesia in patients undergoing off-ptanp coronary artery bypass graft surgery. Methods Forty patients were evenly randomized into sufentanil group and fentanyl group. Anesthesia was induced with propofol ( 1 mg/kg-2 mg/kg) and either sufentanil ( 1 μg/kg-2 μp/kg) or fentanyl (5μg/kg-10 μg/kg), and was maintained Results Light anesthesia responses during intubation and the maintenance of anesthesia was significantly less observed in sufentanil group than that in fentanyl group. Both systolic and diastolic blood pressures were significantly lower during intubafion, skin incision, maintenance of anesthesia and extubation in sufentanil group than those in fentanyl group. The time to opening eyes on command and the time for extuhation after surgery were comparable between the two groups. Conclusion The anesthetic effects of sufentanil are more potent than those of fentanyl. Sufentanil can offer superior intraoperative hemodynamic stability in comparison to fentanyl.[ Key words] sufentanil; general anesthesia; off-pump coronary artery bypass graft Key words: sufentanil; general anesthesia; off-pump coronary artery bypass graft
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