Application of Routine Analysis Procedures to a Direct Mass Spectrometry Technique: Selected Ion Flow Tube Mass Spectrometry (SIFT-MS)

Abstract

In recent years the environmental and human health impacts of volatile organic compounds (VOCs) have become more apparent, resulting in increased analysis demand. The gold-standard chromatographic techniques continue to be employed for most laboratory analyses. However, they have made only modest gains in productivity over the years, and these gains are primarily due to automated sample preparation and injection. Alternatively, significant productivity gains for VOC analysis through faster sample analysis and reduced instrument maintenance could be achieved by adopting direct mass spectrometry techniques such as selected ion flow tube mass spectrometry (SIFT-MS). This article demonstrates that routine analysis techniques such as quality control checks, method validation, the method of standard additions, and internal standards are readily applied to SIFT-MS, simplifying adoption of the technique. In addition, workflows for analysis of chromatographically challenging species are simplified by using SIFT-MS. Sample throughputs are increased two- to 25-fold depending on the analytical procedure.