Abstract
Nanostructured lipid carriers (NLC) could be used as suitable carriers of water-insoluble nutrients such as coenzyme Q10 (CoQ10) improve their bioavailability. The CoQ10-NLC was prepared by high-pressure homogenization method. The freshly prepared CoQ10-NLC showed ellipsoid morphology under atomic force microscope, and the average encapsulation efficiency was about 98.4 ± 0.3%. Good physical and chemical stability was observed by photon correlation spectrum and HPLC, respectively. In 3 months’ storage, the concentration of CoQ10-NLC kept at 8.5 ± 1.5 mg/mL; the particle size was 190 ± 30 nm with polydispersity index (PDI) lower than 0.1. Lyophilization was proved feasible for the storage of NLC dispersion. The formulation also showed the potent possibility of application on beverage. Particle size remained relatively steady in simulated beverage solution for 3 months. The oral bioavailability study was carried out using Wistar rats. The relative bioavailability of CoQ-NLC was about 200% compared with CoQ10 suspension. In conclusion, the NLC formulation showed good stability and improved bioavailability. It demonstrated a promising perspective for daily consuming and industrial production.
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