Abstract
Monolithic columns, consisting of continuous beds with through pores of organic or inorganic matrix, have found increasing applications for HPLC separations. The main advantage of the monolithic technology is the ability to use high flow rates without significant loss of efficiency, leading to very fast separations. The size and shape of the monolith depends on the application. For HPLC, rods and discs made of silica or polymer have been applied. The silica monoliths have bimodal pore structure and large surface area. These have found applications for small molecule analysis. The polymer monoliths have smaller surface area and have been primarily used for the separation of macromolecules1 This paper discusses the recent applications of monolithic columns for HPLC separations.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Liquid Chromatography & Related Technologies
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
