Abstract
BackgroundThis study aimed to construct a biological age assessment formula for the Chinese population and to explore the effectiveness of double filtration plasmapheresis for anti-ageing and longevity.Methods915 subjects were recruited, including 584 (63.8%) males and 331 females (36.2%). Male age was 50.94±10.60 (mean±SD), and female age was 51.20±11.84 (mean±SD). 34 blood markers were detected in the laboratory. The ageing biomarkers were determined by statistical correlation analysis and redundancy analysis, and the biological age assessment formula was established by multiple linear regression analysis. Paired sample T test was used to analyse the elimination effect of double filtration plasmapheresis on aging biomarkers.ResultsBased on the comprehensive blood test and analysis, the ageing biomarkers were screened, and the male and female biological age assessment formulas were established. Then, the elimination of ageing biomarkers by double filtration plasmapheresis was examined. Double filtration plasmapheresis can eliminate ageing biomarkers, with an average of 4.47 years decrease in age for males and 8.36 years for females.ConclusionSo, biological age provides a scientific tool for assessing ageing, and double filtration plasmapheresis is safe and might be effective for anti-ageing and longevity. However, the effect of plasmapheresis is expected to be transient, so further studies are needed to plan the number and range of the plasmapheresis procedures necessary to consistently lower the parameters under study.
Highlights
This study aimed to construct a biological age assessment formula for the Chinese population and to explore the effectiveness of double filtration plasmapheresis for anti-ageing and longevity
Relevant analysis of Alanine aminotransferase (ALT), total protein (TP), ALB, CHE, HCY, Immunoglobulin M (IGM), CYCS, UERA, CERA, GLU, β2M met the requirements (Table 2), which were selected as markers for the redundancy analysis
ALB, IGM, UERA, β2M, GLU, CYCS, HCY were used for the biological age regression analysis (Table 3)
Summary
This study aimed to construct a biological age assessment formula for the Chinese population and to explore the effectiveness of double filtration plasmapheresis for anti-ageing and longevity. The ageing of population is a major social issue around the world since the twentieth century. It is a global and strategic issue in China’s social and economic development. The development of population ageing affects social, economic and family, and has a significant impact on the medical and health field. On April 12, 2008, China Insurance Regulatory Commission issued the China Ageing Social Health Risk Management Report, which showed that the prevalence of chronic diseases among the elderly is 60–70%. If healthy ageing is not adopted to cope with the ageing of population of the whole country, the social and economic development of China will be challenged. To deal with the acceleration of national ageing, healthy ageing is the only right decision
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