Abstract
Phytochemicals as dietary constituents are being explored for their cancer preventive properties. Quercetin is a major constituent of various dietary products and recently its anti-cancer potential has been extensively explored, revealing its anti-proliferative effect on different cancer cell lines, both in vitro and in vivo. Quercetin is known to have modulatory effects on cell apoptosis, migration and growth via various signaling pathways. Though, quercetin possesses great medicinal value, its applications as a therapeutic drug are limited. Problems like low oral bioavailability and poor aqueous solubility make quercetin an unreliable candidate for therapeutic purposes. Additionally, the rapid gastrointestinal digestion of quercetin is also a major barrier for its clinical translation. Hence, to overcome these disadvantages quercetin-based nanoformulations are being considered in recent times. Nanoformulations of quercetin have shown promising results in its uptake by the epithelial system as well as enhanced delivery to the target site. Herein we have tried to summarize various methods utilized for nanofabrication of quercetin formulations and for stable and sustained delivery of quercetin. We have also highlighted the various desirable measures for its use as a promising onco-therapeutic agent.
Highlights
The medicinal properties of various phytochemicals, such as anti-oxidative, anti-inflammatory, antimicrobial and anticancer activities, have been known to mankind since ancient times
Crebelli et al, demonstrated that plasma samples collected from rats, following oral administration of quercetin, lack mutagenic properties whereas fecal and urine samples displayed mutagenicity, suggesting that upon absorption quercetin may get metabolized into non-mutagenic derivatives [66]
A more refined and successful strategy for silica-based quercetin delivery system may be expected in future, utilizing the benefits offered by the silica nanoparticles against cancer
Summary
The medicinal properties of various phytochemicals, such as anti-oxidative, anti-inflammatory, antimicrobial and anticancer activities, have been known to mankind since ancient times. In the search for novel therapeutic drugs various studies have tried to to explore explore the the anticancer potential of of natural natural compounds compounds available available from from fruits fruits and and vegetables, vegetables, tried anticancer potential such as as phytochemicals phytochemicals [14,15,16] As documented, documented, these these phytochemicals phytochemicals showed showed anticancer anticancer activities activities such by modulating various cellular processes and interfering with cancer progression and metastasis by modulating various cellular processes and interfering with cancer progression and metastasis (Figure 1). Keeping all this in view, we discuss the of promising cancer as compared to normal cells [31] Keeping all this view, discuss the promising role of cells nanotechnology-based quercetin delivery systems forincancer therapywe and the various merits and demerits associated with these approaches. Role of nanotechnology-based quercetin delivery systems for cancer therapy and the various merits and demerits associated with these approaches
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