Application of Artificial Bronchial Provocation Test in the Diagnosis of Chronic Cough in Children

Abstract

Objective To evaluation the safety and application value of artificial bronchial provocation tests(BPT)with methacholine(MCH) in children which judged by lung auscultation(AHR). Methods From January 2010 to August 2010, 700 children with chronic cough were included in the study, and divided into ≤3 years old group(n=534)and >3 years old group(n=166). They were all accepted artificial BPT with MCH.Heart rate, breathing, oxygen saturation, cough and pulmonary wheeze were monitored in the process of test. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of the Central Hospital of Mianyang. Informed concent was obtained from each parents. Results The total positive rate of BPT was 80%(560/700). No significant difference was found between ≤3 years old group and >3 years old group(P>0.05). There was no significant difference in vital sign changes between before and after BPT in both groups(P>0.05). All patients had no serious adverse reaction. Conclusions Artificial BPT with MCH is a reliable and safe method for children with chronic cough, and plays an important role in the etiologic diagnosis.This method is suitable for primary hospitals without baby tidal breathing pulmonary function equipment. Key words: artificial bronchial provocation test; methacholine; chronic cough; children