Abstract
The author has described1 the condition of overripeness that develops in frog eggs if fertilization is delayed 3 to 5 days after ovulation. Among the abnormalities of embryonic development that follow, one of the most striking is the frequent appearance of reduplications. In the early gastrulation stage instead of the normal upper blastopore lip of limited extent and regular curvature there often appear long and irregular clefts and folds in the equatorial region. Attempts at gastrulation become visible not only on one side but all around the whole circumference of the embryo. As time progresses multiple blastopores and multiple gastrulation lead to the development of twin embryos. As we have pointed out previously,1 this effect indicates that overripeness has brought about 2 concomitant changes in the embryos. First, the physiological correlations by which an embryo develops as a balanced organism are impaired. These correlations largely rest on inhibitory functions by which established “organizers” (ind...
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