Abstract
Plasma-deoxycorticosterone (DOC) concentration was measured in thirty-one hypertensive patients, all with normal plasma-aldosterone values. Plasma-Doc concentration was persistently high in six of the twenty-one patients with low plasma-renin concentration and in none of the ten cases in whom renin values were normal. There were intermittently raised DOC levels in three further patients with low plasma-renin and in two cases in the normal-renin group. Intermittent hypo- kalæmia was observed in each of the cases with persistently raised plasma-DOC. The possible role of raised DOC levels in the pathogenesis of hypertension and in the suppression of the renin-angiotensin system is discussed.
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