Abstract
Background Acute human immunodeficiency virus type 1 (HIV-1) infection results in dysregulated immunity which contributes to poor control of viral infection. Dendritic cells (DCs) are key regulators of both adaptive and innate immune responses needed for controlling HIV-1 and we surmised that plasma factors elicited during acute HIV1 infection (AHI) may impede DC function. Such inhibitory factors present in AHI plasma include apoptotic microparticles (MPs), small membranous blebs derived from dying cells.
Highlights
Acute human immunodeficiency virus type 1 (HIV-1) infection results in dysregulated immunity which contributes to poor control of viral infection
Apoptotic microparticles generated during acute HIV-1 infection inhibit human dendritic cells via CD44
Dendritic cells (DCs) are key regulators of both adaptive and innate immune responses needed for controlling HIV-1 and we surmised that plasma factors elicited during acute HIV1 infection (AHI) may impede DC function
Summary
Acute human immunodeficiency virus type 1 (HIV-1) infection results in dysregulated immunity which contributes to poor control of viral infection. Dendritic cells (DCs) are key regulators of both adaptive and innate immune responses needed for controlling HIV-1 and we surmised that plasma factors elicited during acute HIV1 infection (AHI) may impede DC function. Such inhibitory factors present in AHI plasma include apoptotic microparticles (MPs), small membranous blebs derived from dying cells
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