Abstract
Measuring mechanisms and timing of cell death is important to distinguish physiological from pathological cellular events or to find suitable cancer therapies. A microplate assay measures apoptosis based on extracellular phosphatidylserine exposure of apoptotic cells. The specific binding of annexin V to phosphatidylserine is converted to a luminescent signal. In parallel, the assay reports on necrosis by a non-permeable fluorescent DNA dye entering only cells with a disrupted cell membrane.
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