Abstract
Hyperlipidemia is one of the main risk factors for coronary artery disease (CAD). In the present study, we aimed to explore whether the single-nucleotide polymorphisms (SNPs) in amyloid precursor-like protein (APLP) 2 (APLP2) gene were associated with high lipid levels in Chinese population in Xinjiang, China. We recruited 1738 subjects (1187 men, 551 women) from the First Affiliated Hospital of Xinjiang Medical University, and genotyped three SNPs (rs2054247, rs3740881 and rs747180) of APLP2 gene in all subjects by using the improved multiplex ligation detection reaction (iMLDR) method. Our study revealed that the rs2054247 SNP was associated with serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) levels, and high-density lipoprotein cholesterol (HDL-C) in additive model (all P<0.05). The rs747180 SNP was associated with serum TC and LDL-C levels in additive model (all P<0.05). Our study revealed that both rs2054247 and rs747180 SNPs of the APLP2 gene were associated with high TC and LDL-C levels in Chinese subjects in Xinjiang.
Highlights
Coronary artery disease (CAD), the leading cause of death, imposes immense health and economic burdens worldwide [1,2,3]
According to The 2016 Chinese Guidelines for the Management of Dyslipidemia in Adults [22]. high total cholesterol (TC) was defined as TC ≥ 6.22 mmol/l, high low-density lipoprotein cholesterol (LDL-C) was defined as LDL-C ≥ 4.14 mmol/l, low high-density lipoprotein cholesterol (HDL-C) was defined as HDL-C ≤ 1.04 mmol/l, and high TG was defined as TG ≥ 2.26 mmol/l
Our results showed that differences in single-nucleotide polymorphism (SNP) rs2054247 and SNP rs3740881 between males and females were not significant
Summary
Coronary artery disease (CAD), the leading cause of death, imposes immense health and economic burdens worldwide [1,2,3]. CAD is a complex disease with the involvement of multiple mechanisms, cell types, and is influenced by multiple risk factors such as diabetes, hyperlipidemia, smoking, chronic inflammation, immune diseases, hypertension, physical inactivity, and genetics [4,5,6]. Hyperlipidemia plays a vital role in CAD development [7]. Studies showed that increased lipid levels result in vessel wall reactions, including endothelial dysfunction, smooth muscle cells proliferation, lipid accumulation, foam cell formation, and, necrosis and plaque development, which were considered to increase the risk of CAD [9,10]. Genetic factors including single-nucleotide polymorphisms (SNPs) are the main risks that contribute to dyslipidemia
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