Abstract
The data on chemical structures and specific activities of compounds functioning as histamine -receptor antagonists, -ATPase inhibitors at the exchange sites of hydrogen ions (proton pump inhibitors) and potassium ions (-competitive acid blockers) published from 1990 to 2013 are surveyed. The antisecretory agents with studied cytoprotective activity or with additional therapeutic properties compensating for disorders of internal defence mechanisms are presented. A separate section is devoted to the drugs that prevent or mitigate the NSAID-induced intestinal damage. All of the considered structures are classified according to the type of biological mechanism of action. Some aspects of the structure – activity relationships for such compounds are considered.The bibliography includes 83 references.
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