Abstract
Antitumor activity of new anthracycline antibiotics aclacinomycin A, MA 144 N1 and MA 144 S 1 was studied on 11 cell lines of ascitic hepatoma in Donryu rats. These compounds showed similar antitumor spectrum against AH hepatoma; moderate effect on AH 13, 44, 66, 66F, 7974 and 60 C in the ip inoculation-ip treatment system. Aclacinomycin A showed a marked antitumor effect on AH 41 C in the iv-iv system, and AH 44 in the iv-ip and iv-po systems. The antitumor spectrum of aclacinomycin A seems to be different from that of adriamycin.
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