Abstract
In recent years, the utilization of Chinese native medicine and other plant extracts in the treatment of diseases has attracted extensive attention, especially in the area of malignant tumors. However, lots of herbal remedies active ingredients have not been found or have been discovered but not effectively developed and applied. Therefore, screening new Chinese medicine active components and determining their antitumor effects have become a new breakthrough in the prevention and treatment of tumor disease. In the past years, a large number of studies have demonstrated that Polygonum cuspidatum and its active components like resveratrol showed excellent antitumor activities, including our own antitumor studies about resveratrol in colorectal cancer. The purpose of this review is to summarize the research progress of Chinese herb Polygonum cuspidatum and its active components in tumor diseases and provide theoretical basis for further scientific experiments and clinical applications.
Highlights
With the changes of the diet types and the bad living habits, malignant tumors have gradually developed into a serious threat to human health and life
In the United States, according to the current peak levels [1], from 1991 to 2014, overall cancer mortality dropped by 25%; in the past 2017 years, 1,688,780 new cancer cases and 600,920 cancer deaths are still expected to occur in USA
The results of the present study showed that polydatin induces apoptosis effectively with an increase in Bax expression and a decrease in Bcl-2 expression in lung cancer cells, providing a theoretical basis for the prevention and treatment of lung cancer by polydatin
Summary
With the changes of the diet types and the bad living habits, malignant tumors have gradually developed into a serious threat to human health and life. The treatment of tumors mainly focuses on surgery, radiation therapy, chemotherapy, molecular targeted therapy, and immunotherapy. These treatments, to some extent, produce side effects on normal cells, organs, and other tissues of the human body, accelerating the death process of cancer patients. Many natural products and their active components have been reported to have potential antitumor or tumor preventive properties. The full utilization of some natural products and their active components will provide unique ideas and methods for cancer prevention and treatment. We believe that it is necessary to systematically summarize the antitumor effects of Polygonum cuspidatum and its active components and lay a foundation for their clinical development and application
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