Abstract
Female Fischer 344 rats bearing the R3230AC mammary tumor were treated with three different inhibitors of cyclooxygenase--indomethacin, ibuprofen, and flurbiprofen (5 mg/kg body weight). After three weeks, the weight and volume of tumors from treated animals were smaller than those of control rats. Rats bearing the same tumor but immunized against PCE 2 conjugated to bovine serum albumin showed similar trends in tumor grown inhibition. Thus we conclude that PGE 2 plays an important role in the establishment and growth of the R3230AC mammary tumor.
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