Abstract
In this study, the antithrombotic activity of a new chemical compound of a benzimidazole derivative, which has a shielded phenolic substituent in its structure, under the laboratory code RU-1144 was studied, which exhibits high antiplatelet and antioxidant activity in vitro and in vivo tests. It was shown that the test sample has a pronounced antithrombotic effect and is superior in activity to the comparison drugs acetylsalicylic acid and clopidogrel in a model of cell thrombosis generated in mice.
Highlights
In this study, the antithrombotic activity of a new chemical compound of a benzimidazole derivative, which has a shielded phenolic substituent in its structure, under the laboratory code RU-1144 was studied, which exhibits high antiplatelet and antioxidant activity in vitro and in vivo tests
It was shown that the test sample has a pronounced antithrombotic effect and is superior in activity to the comparison drugs acetylsalicylic acid and clopidogrel in a model of cell thrombosis generated in mice
Антитромботическая активность нового гипогликемического соединения лимиглидола на модели клеточного тромбоза у мышей // Бюллетень экспериментальной биологии и медицины
Summary
The antithrombotic activity of a new chemical compound of a benzimidazole derivative, which has a shielded phenolic substituent in its structure, under the laboratory code RU-1144 was studied, which exhibits high antiplatelet and antioxidant activity in vitro and in vivo tests. РЕЗУЛЬТАТЫ ИССЛЕДОВАНИЯ И ИХ ОБСУЖДЕНИЕ При исследовании антитромботического действия соединения РУ-1144 на модели генерализованного адреналин-коллагенового тромбоза была продемонстрирована его высокая активность. Введение соединения РУ-1144 и препаратов сравнения ацетилсалициловой кислоты и клопидогрела достоверно повышало выживаемость мышей при создании данной модели тромбоза до 80, 60 и 50 % соответственно
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