Abstract
BACKGROUND: Titanium alloy (Ti) has been used for long-term blood pumps as a good blood compatible material. However, thrombus formation induced by activation of coagulation cascade or platelet sometimes contributes to fatal pump failure. In this study, we formed titania-gel (Ti-Gel) on the Ti surface and evaluated its feasibility as a new blood compatible material in a static condition. METHODS: The Ti plate was chemically treated to form the gel on the surface. Whole blood was used for blood coagulation test. The ratio of blood coagulation was calculated from free hemoglobin in red blood cells, which were not trapped in the thrombus. Platelet rich plasma was used for platelet adhesion test and platelets were activated with adenosine diphosphate. The status and number of adhering platelets on the surface of plates were evaluated by scanning electron microscope (SEMI and enzymatic reaction. RESULTS: Blood coagulation ratios on the Ti and Ti-gel were 80.5 % and 52.1 % at 15 minutes, 99.9 % and 97.1 % at 30 minutes. Deformation to spinate shapes of platelets for adhering on the surface of plates and its enhancement of platelet aggregation were observed by SEM studies. Compared with the Ti, Ti-gel reduced the adhering platelets by 17.3%. CONCLUSION: Ti-Gel has an appropriate antithrombogenic property because of its anti-platelet and anti-blood coagulation effect.
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