Abstract
The effect of a complex herbal remedy on the function of the central nervous system in rats on a model of chronic unpredictable mild stress was studied in the present work. The level of stress disorders was determined by the behavioral responses in rats using the methods of “open field”, “elevated plus maze”, “forced swimming test” and “tail suspension model”, weights of target organs. It is established that the complex herbal remedy has adaptogenic, anti-stress and antidepressant effects. (For citation: Muruev BA, Gulyaev SM, Shantanova LN, Mondodoev AG. Antistress and antidepressant activity of a plant drug in a mild chronic stress model. Reviews on Clinical Pharmacology and Drug Therapy. 2018;16(2):69-73. doi: 10.17816/RCF16269-73).
Highlights
The effect of a complex herbal remedy on the function of the central nervous system in rats on a model of chronic unpredictable mild stress was studied in the present work
It is established that the complex herbal remedy has adaptogenic, anti-stress and antidepressant effects
The chronic mild stress (CMS) model of depression: History, evaluation and usage
Summary
Противострессовое и антидепрессивное действие растительного средства при хроническом умеренном стрессе // Обзоры по клинической фармакологии и лекарственной терапии. В настоящей работе проведено исследование влияния комплексного растительного средства на функции ЦНС у крыс на модели хронического непредсказуемого умеренного стресса. Antistress and antidepressant activity of a plant drug in a mild chronic stress model. The effect of a complex herbal remedy on the function of the central nervous system in rats on a model of chronic unpredictable mild stress was studied in the present work. Keywords: chronic mild stress; depression; herbal remedy; adaptogenes; antidepressant effect. Хронический стресс, как результат длительного воздействия различных стрессовых факторов и напряжения защитных ресурсов организма человека, может являться главной причиной развития психосоматических заболеваний, а также невротических и глубоких депрессивных расстройств. Целью настоящего исследования явилось определение противострессового и антидепрессивного действия комплексного растительного средства при хроническом умеренном стрессе
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