Abstract
The antinociception induced by supraspinally administered β-endorphin is mediated by the release of Met-enkephalin and subsequent stimulation of δ-opioid receptors from the spinal cord in mice. Repeated intrathecal administration of an antisense oligodeoxynucleotide against δ-opioid receptors selectively attenuated i.c.v. administered β-endorphin-induced antinociception without any effect on the antinociception induced by μ-opioid receptor agonists, morphine and DAMGO, or κ-opioid receptor agonists, U50,488H. A random sequence oligodeoxynucleotide was inactive against β-endorphin-induced antinociception. The study confirms previous findings that the antinociception induced by β-endorphin is mediated by the stimulation of the δ-opioid receptors in the spinal cord.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
