Abstract
Antiresorptive and Anabolic Bone Therapy Does not Improve Weight Bearing Capacity and Bone Strength in OA Rats
Highlights
Osteoarthritis (OA) of the knee is the most common type of arthritis, and as such, it is the main cause of pain and disability in the elderly [1,2]
The incapacity of the osteoarthritic limb to withstand physiologic loads is a critical element in OA pathophysiology; the reestablishment of mechanical function through moderate exercise is recommended for the management of OA patients [12,13]
The MM rats showed a different pattern of weight distribution compared with the sham controls
Summary
Osteoarthritis (OA) of the knee is the most common type of arthritis, and as such, it is the main cause of pain and disability in the elderly [1,2]. There is a clear need to reestablish joint functionality in these patients because mechanical loads are critical to maintaining the health of the articular cartilage, bone, and muscles [5,6]. Because no effective therapies that target chondrocytes exist, clinical guidelines recommend both pharmacological and nonpharmacological approaches to relieve the symptoms of OA [14]. Both bone and cartilage turnover are deemed critical for the health of synovial joints, the use of both antiresorptive and anabolic bone agents could be used to treat OA symptoms [15,16]. Preclinical data overwhelmingly indicate that antiresorptive [17,18] and anabolic [19,20] therapies curb progression of OA in animal models, clinical results fail to demonstrate clear benefits of these therapies to OA patients despite the fact that these drugs have been in clinical use for many years [21,22]
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