Abstract
This chapter discusses the adverse effects of antipsychotic drugs. Hypotension, syncope, and sudden death might be a continuum of events caused by antipsychotic drugs in some predisposed patients. Syncope is frequent in elderly people, and its consequences account for substantial mortality, morbidity, and disability. Antipsychotic drugs and sedatives are contraindicated during acute attacks of asthma as sedation hampers respiratory drive. The risks of asthma death and hospital readmission are increased among users of psychotropic drugs. Drug-induced stuttering has been reported with neuroleptic drugs. Most of the adverse events with haloperidol are attributable to extrapyramidal symptoms and include akathisia and akinesia. The most common adverse effects of fluspirilene include fatigue, weight gain, and mild Parkinson-like symptoms. Adverse effects such as persistent extrapyramidal symptoms, tardive dyskinesia, and hyperprolactinemia are indications for switching. Cocaine blocks dopamine reuptake, thereby resulting in the potentiation of neurotransmission. Chronic use of cocaine eventually causes the depletion of dopamine. Extrapyramidal adverse effects may cause subjective dysphoria in some schizophrenic patients and contribute to depressive symptoms.
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