Abstract
Antiplasmodium activity test of methanol extract of leaves of kelwih (Artocarpus camansi) was carried out in vivo in mice (Mus musculus) Balb / c infected with Plasmodium berghei. The purpose of this study was to determine the effective dose of methanol extract of leaves of kelwih as antiplasmodium. Antiplasmodium activity test was carried out in vivo in Balb / c mice that had been infected with Plasmodium berghei. Parameters observed were parasite growth, and parasite inhibition. After the administration of methanol extract of leaves of kelwih and as many as 30 mice were grouped into 5 treatment groups which were given extract doses of 1, 25, 50, 75, and 100 mg / kg BB and one negative control group (without the administration of methanol extract of kelwih leaves). Observations were carried out for 7 days, starting from day 0 (before treatment), 4 days during treatment and 2 days after treatment. The data obtained were analyzed statistically ANOVA using the Kruskal-Wallis H test and continued with Mann-Whitney U test. The results showed that the lowest parasite growth (1.636%) was obtained from the group dose of 100 mg / kg BB, the largest parasite inhibition (72.832% ) also produced by a group dose of 100 mg / kg BB. An extract is said to have positive antimalarial activity if it can reduce parasitemia by 30% or more. A dose of 100 mg / kg body weight produces parasitic growth values, and parasite inhibition is significant to the control (p <0.05). So, from the explanation above, it can be concluded that giving a dose of 100 mg / kg BB of methanol extract of leaves of kelwih has potential activity as an antimalarial.
Highlights
ABSTRAK: Uji Aktivitas antiplasmodium ekstrak metanol daun keluwih (Artocarpus camansi) dilakukan secara in vivo pada mencit (Mus musculus) Balb/c yang diinfeksi dengan Plasmodium berghei
Antiplasmodium activity test of methanol extract of leaves of kelwih (Artocarpus camansi) was carried out in vivo in mice (Mus musculus) Balb / c infected with Plasmodium berghei
The results showed that the lowest parasite growth (1.636%) was obtained from the group dose of 100 mg / kg BB, the largest parasite inhibition (72.832% ) produced by a group dose of 100 mg / kg BB
Summary
Secara umum kelompok yang diberi perlakuan dengan ekstrak daun keluwih ratarata pertumbuhan parasitnya lebih rendah jika dibandingkan dengan kelompok kontrol pertumbuhan parasit yang paling rendah terjadi pada kelompok dosis 100 mg/kg BB sebesar 1,636 %, sedangkan pertumbuhan parasit yang paling besar adalah pada kelompok kontrol sebesar 6,023 %. Hasil uji pengaruh antar kelompok dengan tingkat kepercayaan 95% menunjukkan bahwa ekstrak daun keluwih dapat menekan pertumbuhan parasit P.berghei
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