Abstract
The antioxidative effects of dietary α-tocopherol (TOC) and riboflavin-tetrabutyrate (RTB) against tissue lipoperoxidation caused by the long-term administration of methyl linoleate hydroperoxide (HPO) to rats were investigated by measuring the spontaneous chemiluminescence (CL) intensities and thiobarbituric acid (TBA) reactants of the liver, lung and heart.TOC supplementation resulted in the effective decrease of CL intensities and TBA reactants in the three organs, while RTB supplementation led to the definitive decay of both indices of the lung and a significant decrease in the CL intensity of the heart, as compared with those of rats dosed with HPO and not given any supplemental antioxidant.Although the activities of glutathione peroxidase and glutathione reductase in the three organs obtained from rats dosed with HPO for 29 days were clearly lower than those of the control rats, both enzyme activities in rats dosed with antioxidants other than HPO were generally maintained at levels almost equal to ...
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