Abstract
Antioxidative activities of alpha-mangostin in high-fat/high-glucose diet and streptozotocin-induced insulin-resistant rodents
Highlights
Type 2 diabetes mellitus as caused by insulin resistance (IR) is the ninth leading cause of death, afflicting approximately one-tenth of adult population worldwide
Recent evidence suggests that alpha-mangostin (α-MG) is a potential candidate to ameliorate oxidative stress; this study aims to evaluate the antioxidative properties of α-MG in Insulin resistance (IR)-induced rats
Recent evidence suggests that α-MG yielded potent antioxidative potentials, little is known regarding its effects on the oxidative markers of various organs and skeletal glucose transporter type 4 (GLUT4) expressions in IR
Summary
Type 2 diabetes mellitus as caused by insulin resistance (IR) is the ninth leading cause of death, afflicting approximately one-tenth of adult population worldwide. The high mortality rate of this disease may be explained by the amplified risk of multisystemic complications, including cardiovascular disease, stroke, nephropathy, retinopathy, and neuropathy (Zheng et al, 2018). The pathomechanism of this disease involves impairment in insulin secretion and/or action as characterized by decreased glucose transporter type 4 (GLUT4) expression, both of which are mediated by oxidative stress (Asmat et al, 2016). Recent evidence suggests that α-MG yielded potent antioxidative potentials, little is known regarding its effects on the oxidative markers of various organs and skeletal GLUT4 expressions in IR. This study aims to evaluate the effects of α-MG in oxidative stress and skeletal GLUT4 expressions in IR model rats
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