Abstract
Recently, the occurrence of cancer has significantly increased; it represents the second-most frequent cause of death after cardiovascular diseases. Many dietary antioxidants have shown large impact as effective agents for cancer prevention by reducing oxidative stress, which has been a part in the development of many diseases, including cancer. One of the obstacles in the delivery of antioxidant therapies into the required domain lies in the inadequate delivery of these agents to their intended site of action. Using nanotechnology in delivery of antioxidants leads to increased therapeutic index and higher drug concentration in tumor tissues, thus enhancing anticancer treatment. In this review, we discuss the role of different antioxidants in cancer therapy and their improved therapeutic effect through their formulation using nanotechnology.
Highlights
Cancer is considered the second most frequent cause of death worldwide after cardiovascular disease
Various researchers have reported the mechanism by which oxidative stress can lead to chronic inflammation, which leads to many diseases including cancer [3]
The generation of oxidative stress is caused by the imbalance between reactive oxidative stress production and the deficiency of the cell antioxidant defense system [8]
Summary
Cancer is considered the second most frequent cause of death worldwide after cardiovascular disease. Low concentrations of ROS compounds are required for signal transduction, but a cancer cell has an accelerated metabolism, they need high ROS concentrations to maintain their high proliferation rate They cause damage in mitochondrial DNA, which leads to mutation in the oxidative phosphorylation resulting in increase in production of ROS. It aids in the proliferation of cancer cells, which leads to an increase in tumor growth [6]. The generation of oxidative stress is caused by the imbalance between reactive oxidative stress production and the deficiency of the cell antioxidant defense system [8] This imbalance leads to damage of important cells as it affects the whole organism. Recent reviews proved that administration of antioxidants with chemotherapy has the following advantages: (a) they do not interfere with chemotherapy and (b) they improve the cytotoxic effect of chemotherapy while protecting the normal tissue increase the patient survival and therapeutic response [17,18]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
