Abstract
The oxidation of the antioxidants dihydrolipoate and lipoamide by triplet duroquinone (3DQ) has been studied by laser flash photolysis and time-resolved resonance Raman (TR3) spectroscopy. Reaction of3DQ with lipoamide by electron transfer [k(H2O)/k(D2O ∼ 1] was more rapid than with dihydrolipoate, in which a proton is also involved [k(H2O)/k(D2O ∼ 2]. For dihydrolipoate at neutral pH the undeprotonated form was the major reactive species with k ∼ 109dm3mol−1s−1. At higher pH values the reaction of ionised (thiolate) forms was observed with k ≥ 4 × 109dm3mol−1s−1. The electron transfer mechanism of reaction between3DQ and lipoamide was confirmed by TR3spectra in which formation of the durosemiquinone radical anion and lipoamide disulfide radical cation (RSS+•) was observed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biochemical and Biophysical Research Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
