Abstract
Oxidative stress is one of the important etiologies of premature ovarian insufficiency (POI). Coenzyme Q10 (CoQ10), as a lipid-soluble benzoquinon, is an antioxidant in the mitochondrial respiratory chain. The deficiency of CoQ10 can increase oxidative stress of oocytes, which induces mitochondrial dysfunction and accelerates granulosa cell apoptosis, diminishing ovarian reserve finally. The supplementation of CoQ10 may preserve ovarian reserve and improve ovulation rates and oocyte quality. This review describes the antioxidant of CoQ10 and its effect on the function of ovary. Key words: Coenzyme Q10; Oxidative stress; Ovarian function; Premature ovarian insufficiency; Antioxidant
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