Abstract
BackgroundEpidemiological and in vitro studies suggest that antioxidants such as quercetin and vitamin E (VE) can prevent lung tumor caused by smoking; however, there is limited evidence from animal studies.MethodsIn the present study, Swiss mouse was used to examine the potential of quercetin and VE for prevention lung tumor induced by smoking.ResultsOur results suggest that the incidence of lung tumor and tumor multiplicity were 43.5% and 1.00 ± 0.29 in smoking group; Quercetin has limited effects on lung tumor prevention in this in vivo model, as measured by assays for free radical scavenging, reduction of smoke-induced DNA damage and inhibition of apoptosis. On the other hand, vitamin E drastically decreased the incidence of lung tumor and tumor multiplicity which were 17.0% and 0.32 ± 0.16, respectively (p < 0.05); and demonstrated prominent antioxidant effects, reduction of DNA damage and decreased cell apoptosis (p < 0.05). Combined treatment with quercetin and VE in this animal model did not demonstrate any effect greater than that due to vitamin E alone. In addition, gender differences in the occurrence of smoke induced-lung tumor and antioxidant intervention were also observed.ConclusionWe conclude that VE might prevent lung tumor induced by smoking in Swiss mice.
Highlights
Epidemiological and in vitro studies suggest that antioxidants such as quercetin and vitamin E (VE) can prevent lung tumor caused by smoking; there is limited evidence from animal studies
The Beta-Carotene Tumor Prevention Study Group demonstrated that beta-carotene may promote the development of lung tumor in male smokers rather than prevent the disease [4], the majority of epidemiological findings support the preventive effects of antioxidants, including quercetin and vitamin E (VE), on smoke-induced lung tumor [5,6,7,8,9,10,11]
After exposure to tobacco smoke (TS) for 10 to 20 weeks, female mice exhibited much lower body weight gain compared with their counterparts in control group (p < 0.05), which returned to a basal level after TS withdrawal (Figure 1)
Summary
Epidemiological and in vitro studies suggest that antioxidants such as quercetin and vitamin E (VE) can prevent lung tumor caused by smoking; there is limited evidence from animal studies. Increasing attention has been paid to searching for effective approaches to the prevention and treatment of smokeinduced lung tumor, including the use of antioxidants. The Beta-Carotene Tumor Prevention Study Group demonstrated that beta-carotene may promote the development of lung tumor in male smokers rather than prevent the disease [4], the majority of epidemiological findings support the preventive effects of antioxidants, including quercetin and vitamin E (VE), on smoke-induced lung tumor [5,6,7,8,9,10,11]. To our knowledge, no animal studies have addressed the potential of quercetin and VE for intervening in the development of smoke-induced lung tumor
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
