Abstract
<p>The acid 2,4-dichlorophenoxyacetic (2,4-D), agrochemical widely applied to the improvement of the agricultural productivity, is recognized as extremely toxic, once that its effects are accompanied by the occurrence of oxidative stress. On this context it becomes fundamental to explore components that are able to reduce the damages caused to the organism by this pesticide. The <em>P. Peruviana</em>, is a plant known that it presents components which contribute to the neutralization of the reactive species. Thus, this study had as purpose to evaluate the effect of <em>P. Peruviana</em> fruit aqueous extract on the bio-markers of oxidative stress in erythrocytes exposed to the 2,4-D. The exposition of samples to the 2,4-D has been done, followed to the treatment of these ones with different concentrations of the <em>P. Peruviana</em> Extract (1; 10; 25; 50 e 83 g/L). The results show an increase of the TBARS, PCs, and GSH after the exposure to the 2,4-D. On the other hand, after the treatment of the samples there was a reduction of the PCs and GSH levels in all the treated groups, and a decrease of the lipid peroxidation levels on the groups that were exposed to the Extract on the concentrations of 1 and 10g/L. The results show that the <em>P. Peruviana</em> owns an effect on the antioxidant system of the organism, viewing that it stimulated the consumption of GSH and thus it was able to fix damages in lipids and proteins provoked by 2,4-D specially on the concentrations of 1 and 10 g/L.</p>
Highlights
Environmental contamination caused by increasing and indiscriminate use of pesticides has generated a lot of concerns about the behavior of either the environment or their negative influence on human health (Campos & Vieira, 2002)
It has known that the pesticides, among them the 2,4-D, can cause effects on the biochemical functions, physiological dysfunction and disturb on the energetic metabolism of the alive organisms, affecting the integrity of the membrane inducing the production of Oxygen Reactive Species (EROs), taking to the occurrence of oxidative stress (Sancho et al, 2009, 2010)
After the exposure of the erythrocytes to the herbicide 2,4-D, there was an increase of the Thiobarbituric Acid Reactive Substances (TBARS) levels (Figure 1), of the Protein Carbonyls (PCs) (Figure 2) and of the GSH (Figure 3)
Summary
Environmental contamination caused by increasing and indiscriminate use of pesticides has generated a lot of concerns about the behavior of either the environment or their negative influence on human health (Campos & Vieira, 2002). The clorofenoxiacetical herbicides such as acid 2,4-dichlorophenoxyacetic (2,4-D), are used to kill weeds due to their chemical properties, these compounds are similar to auxin, the plant growth hormone, causing overstimulation of growth that will culminate with his death (Oruç, Sevgiler, & Üner, 2004). Considering that, increase in ERs or the antioxidant www.ccsenet.org/jas
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