Abstract
BackgroundThis study was subjected to investigate different pharmacological properties of ethanol extract of Solena amplexicaulis root.ResultsThe extract contains flavonoid, alkaloid, saponin and steroid compounds. The extract exhibited excellent antioxidant activity in DPPH radical scavenging activity. The extract also showed potent activity in brine shrimp lethality bioassay. The LC50 value was found to 44.677 μg/ml. The extract showed better anti-bacterial activity against gram-negative bacteria. In antifungal assay, the maximum 79.31% of anti-mycotic activity was observed against Aspergillus ochraceus while minimum 44.2% against Rhizopus oryzae. MIC value ranged between 1500–3000 μg/ml. The extract was found moderately toxic with a 24-hr LD50 value of 81.47 mg/kg in Swiss albino mice. The degree of inhibition by the ethanolic extract of the root was found less than that of standard analgesic drug diclofenac sodium. The extract also showed moderate anti-inflammatory and antinociceptive activity and anti-diabetic property. Reducing power of the extract was comparable with standard ascorbic acid. Moderate in vitro thrombolytic activity, lipid peroxidation inhibition property, metal chelating ability and stress-protective activity was also observed.ConclusionEthanol extract of Solena amplexicaulis root can be valuable for treatment of different diseases.
Highlights
This study was subjected to investigate different pharmacological properties of ethanol extract of Solena amplexicaulis root
Phytochemical screening Qualitative phytochemical tests of Solena amplexicaulis were performed for the ethanol extract of the root
Total phenol and flavonoid content and total ascorbic acid content The total phenol and total flavonoid contents of Solena amplexicaulis root of ethanol extract were expressed in Gallic acid and Quercetin equivalents respectively
Summary
This study was subjected to investigate different pharmacological properties of ethanol extract of Solena amplexicaulis root. Medicinal plant extracts are potential source for the development of new agents effective against infections currently difficult to treat. The most important bioactive substances are alkaloid, tannin, flavonoid and phenolic [14]. It is distributed in China, India, Malaysia, Myanmar, Nepal, Pakistan, and Srilanka. Except anti-inflammatory activity [16] antioxidant [12] and antibacterial [17] of Solena amplexicaulis there is no published work on the pharmacological effect of root extracts of the plant. The present study was considered worthwhile to determine the antioxidant, antimicrobial, cytotoxic, toxic and analgesic properties of crude extract of the root of the plant
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