Abstract
In this study, Myrmecodia platytyrae (MyP) water extract was investigated to explain the antioxidant property and its safety. Water extract of MyP was prepared and tested for ORAC for each batch of preparations. The MyP water extract was administered daily onto three groups of experimental animals which were Low Dose (LD), Medium Dose (MD) and High Dose (HD) groups for a period of consecutive 28 days according to the OECD GLP guideline (OECD TG 407). The ORAC results showed that MyP water extract has an antioxidant activity for each batch. The subchronic toxicity test showed that MyP water extract product has no observable sub-chronic toxic effect on Sprague Dawley rats. The body weight of rats increased along with proportional food and water intake. In the same way, all hematological, biochemical parameters as well as histopathological observation do not show any abnormal finding. Gross observations, feed and water consumption, urine strip test and animals’ weight during necropsy did not show any difference compared to the control group. In conclusion, MyP water extract is suggested to have a broad safety margin in experimental animals.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Malaysian Journal of Medical and Biological Research
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
