Abstract
Radiation therapy for head and neck cancer and radioactive iodine for thyroid cancer have been linked to hypothyroidism. Also, whereas standard cytotoxic agents usually do not affect thyroid function, a number of targeted agents have been associated with thyroid gland dysfunction, and therapies that modulate immunologic function have been hypothesized to result in thyroid disease. Now, investigators have conducted a thorough literature review and have assessed the frequency of thyroid dysfunction associated with various agents. Their findings and recommendations are summarized as follows: Tyrosine kinase inhibitors: TKIs, with the exception of erlotinib and gefitinib, have been associated with thyroid dysfunction. Hypothyroidism can develop in patients with previously normal thyroid function or adequately replaced hypothyroidism. In either setting, patients might present with typical …
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