Abstract
Twenty-three alkaloids and five steroids and triterpenes have been isolated and identified from the root bark and stem bark of a Nigerian Tabernaemontana pachysiphon. The following bases have not previously been obtained from this species: isositsirikine, 16-epiisositsirikine, normacusine B, 16-epiaffinine, anhydrovobasindiol, tubotaiwine, ibogaline, isovoacangine, voacamine, lochnericine, 3 R-hydroxyconopharyngine, 3 S-hydroxyconopharyngine and 11-demethylconoduramine, the last three being new alkaloids. The dimeric indole alkaloids and 3 R/S-hydroxyconopharyngine were shown to possess strong antibacterial activity against Gram-positive bacteria and the dimers against Gram-negative bacteria also.
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