Abstract
A series of eighteen azomethines has been synthesized by the reaction of appropriate primary aromatic amines with aryl and/or heteroaryl carboxaldehydes. The synthesized azomethines have been evaluated for their in vitro antileishmanial, antibacterial and antifungal activities. The results revealed some antifungal activity of most of the synthesized compounds, whereas the antileishmaniasis activity results highlighted that all synthesized azomethines inhibited parasite growth and most of them showed highly potent action towards Leishmania major promastigotes. No remarkable bactericidal activities were observed.
Highlights
A series of eighteen azomethines has been synthesized by the reaction of appropriate primary aromatic amines with aryl and/or heteroaryl carboxaldehydes
Leischmaniasis, considered a serious public health concern in many countries, is one of these diseases. It is endemic in many parts of Pakistan and Balochistan and the Upper Sindh are vulnerable to cutaneous leishmaniasis
Azomethines are characterized by the –CH=N- which has special importance in elucidating the mechanism of transmination and racemization in biological system [7,8,9]
Summary
A series of eighteen azomethines has been synthesized by the reaction of appropriate primary aromatic amines with aryl and/or heteroaryl carboxaldehydes. It has been reported that when some aldehydes were functionalized by condensation with various amines, the resulting azomethines had antiparasitic activities [26]. The present work is a continuation of our ongoing programme devoted to the utilization of simple and readily obtainable materials in the synthesis of different biologically active compounds [27,28,29,30,31,32,33], aiming at the same time to seek a cure for the cutaneous antileishmaniasis facing our society in Pakistan by presenting some cheap azomethines that might be useful in antileishmanial and antifungal drug development.
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